COVID-19 Vaccine Basically Optimism For the reason that Exercised Treatment methods Omit to Demonstrate to Good results?
Even with almost a year of its worldwide invasion the SARS-Cov-2 virus called COVID-19 continues to take pleasure from an edge over humankind which will be not surprising thinking about the unprecedented crisis earned by a disease hardly proven to anybody, its seemingly selective approach when it comes to mildness or severity of the infection, baffling all medical scientists and doctors. Humankind, in its present very advanced stage of the knowledge search, is never an event to just accept defeat, and therefore, the quest has been relentlessly going on throughout for a powerful vaccine, and meanwhile intent research on anti-viral or anti-malarial repurposed drugs, plasma therapy and other possible types of treatment. The priority of efforts coming to least to lessen the mortality rates which also differ country-wise and inexplicably, and till today it has been an accepted fact that there surely is no cure for the disease. Various vaccine projects in a variety of stages of development come in full swing in a variety of countries with a lot of them promising a vaccine by the brand new year day or early next year. Now, the newest disappointing developments on treatment methods practiced so far have posed the most relevant question: is a powerful vaccine only a cure for humankind?
The majority of us remember the desperate international craving for a basically Indian anti-malarial drug called Hydroxychloroquine (HCQ) once the pandemic was raging furiously in Europe and the US, and the US President going to the extent of threatening India if supplies of HCQ were not. However, slowly over time this drug was found ineffective and a little harmful too in respect to natural immunity โควิด 19. Then there have been other drugs and steroids which were combined with seemingly hopeful results, Remdesivir being the one most welcomed one as a life-saver.
The outcomes of the Solidarity Clinical Trial, one of many largest international Randomized Controlled Trials (RCT), that’s been conducted by the World Health Organization (WHO) since March 2020 were declared recently which marked four of the very most promising drugs as ineffective in reducing mortality. The four evaluated treatment methods, HCQ, Remdesivir, Lopinavir or Ritonavir and Interferon, have now been found to possess little if any affect mortality rates. In terms of the RCTs conducted in a variety of countries of the planet including in China are worried there will always be doubts on their findings, and experts feel the need for more such studies. Objections were raised against the Solidarity Trial too as regards to its sampling methodology from various quarters, with one Indian hospital refusing to stop using Remdesivir claiming its benefits within the months in their patients. However, technically, it means that with the exception of Corticosteroids which have been proven effective in treating critical patients there is no other deemed treatment method, and it also must certanly be remembered that steroids aren’t recommended for less-severe or general patients.
More disappointing news came next from the Indian Council of Medical Research (ICMR) on the efficacy of the Convalescent Plasma Therapy (CPT), so far permitted as an investigational therapy in progressive stages of the disease in India, which involves taking out blood plasma from recovered COVID-19 patients and injecting this antibody-rich extract into positive patients, particularly the more severe ones treated in hospitals. Over the months it has been progressed into a systematic treatment method creating proper channels of donations over the states as infected doctors too caused it to be an indicate donate the precious plasma.
The Director General of the ICMR declared the outcome on 20th October 2020 after conducting its RCT during April-July period of the season covering over 400 hospitals across 39 medical centers of the country. Based on the results the ICMR has concluded that the CPT fails to lessen the mortality rates or prevent the progression of COVID-19 infections from moderate to severe stages. Following this locating the Government of India is mulling removal of CPT from its COVID-19 protocol for national clinical management. This really is indeed sad news as CPT is a popular approach to COVID-19 treatment in the lack of a powerful vaccine.
Experts, however, aren’t convinced about the CPT results saying that it could experienced related to the delay of the infusion and the grade of the antibodies. Internationally, the CPT continues to be remedy method meant only for emergency use. Anyway, in view of these findings the importance of discovering a powerful vaccine grows even more. The pandemic is definately not keeping its clutches off humankind yet: after over six months of haphazard acceleration India has finally reached its peak in the 3rd week of September 2020 with new cases still hovering around fifty thousand each day and 500+ daily deaths whilst the European countries and the US are experiencing another wave.
Chinmay Chakravarty is just a professional specialized in the creative field with over 2 full decades of experience in journalistic writing, media co-ordination, film script writing, film dubbing, film & video making, management of international film festivals and editing of books & journals. Proficient in providing professional services in these related fields. Was an officer of Indian Information Service and superannuated from the post of Director, Press Information Bureau, Kolkata in November, 2019. Published his first solo book’Laugh and Let Laugh’in 2017.Read More